Fagète S, Fischer N. BioDrugs. 2011 Dec 1;25(6):357-64. doi: 10.2165/11594690-000000000-00000. PMID: 22050338 [PubMed - in process]
Fukata M, Shang L, Santaolalla R, Sotolongo J, Pastorini C, España C, Ungaro R, Harpaz N, Cooper HS, Elson G, Kosco-Vilbois M, Zaias J, Perez MT, Mayer L, Vamadevan AS, Lira SA, Abreu MT. Inflamm Bowel Dis. 2011 Jul;17(7):1464-73. doi: 10.1002/ibd.21527. Epub 2010 Nov 15.
Fagète S, Rousseau F, Magistrelli G, Gueneau F, Ravn U, Kosco-Vilbois MH, Fischer N. The dual specificity of anti-CXCL10-CXCL9 antibodies is governed by structural mimicry.
J Biol Chem. 2011 Oct 31.
Montecucco F, Braunersreuther V, Lenglet S, Delattre BM, Pelli G,
Buatois V, Guilhot F, Galan K, Vuilleumier N, Ferlin W, Fischer N, Vallée JP,
Kosco-Vilbois M, Mach F.Eur Heart J. 2011 May 23. [Epub ahead of print]
Magistrelli, G., et al., Robust recombinant FcRn production in mammalian cells enabling oriented immobilization
for IgG binding studies, J. Immunol. Methods (2011), doi:10.1016/j.jim.2011.09.002
Céline Beauvillain, Pierre Cunin, Andrea Doni, Mari Scotet, Sébastien Jaillon, Marie-Line Loiry,Giovanni Magistrelli, Krzysztof Masternak, Alain Chevailler, Yves Delneste and Pascale Jeannin CCR7 is involved in the migration of neutrophils to lymph nodes 2011 Blood 117: 1196-1204
Nicolas Fischer Sequencing antibody repertoires: The next generation
Volume 3, Issue 1 January/February 2011 On-line publication
2010
Lissilaa R, Buatois V, Magistrelli G, Williams AS, Jones GW, Herren S,
Shang L, Malinge P, Guilhot F, Chatel L, Hatterer E, Jones SA,
Kosco-Vilbois MH, Ferlin WG. Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity. J Immunol. 2010 Nov 1;185(9):5512-21. Epub 2010 Sep 24.
U. Ravn, F. Gueneau, L. Baerlocher, M. Osteras, M. Desmurs, P. Malinge, G. Magistrelli, L. Farinelli, M.H. Kosco-Vilbois, and N. Fischer
By-passing in vitro screening—next generation sequencing technologies applied to antibody display and in silico candidate selection
Nucl. Acids Res. first published online September 15, 2010
doi:10.1093/nar/gkq789
Buatois V, Fagète S, Magistrelli G, Chatel L, Fischer N, Kosco-Vilbois MH, Ferlin WG. Pan-CC Chemokine Neutralization Restricts Splenocyte Egress and Reduces Inflammation in a Model of Arthritis. J Immunol. 2010 Aug 15;185(4):2544-54. Epub 2010 Jul 19.
Garin A, Meyer-Hermann M, Contie M, Figge MT, Buatois V, Gunzer M, Toellner KM, Elson G, Kosco-Vilbois MH. Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.
Immunity. 2010 Jul 23;33(1):84-95.
Magistrelli G, Malinge P, Lissilaa R, Fagète S, Guilhot F, Moine V, Buatois V, Delneste Y, Kellenberger S, Gueneau F, Ravn U, Kosco-Vilbois M, Fischer N. 2010 Rapid, simple and high yield production of recombinant proteins in mammalian cells using a versatile episomal system. Protein Expr Purif. 72:209-216 PubMed PMID: 20399863
van der Woude CJ, Stokkers P, van Bodegraven AA, Van Assche G, Hebzda Z, Paradowski L, D'Haens G, Ghosh S, Feagan B, Rutgeerts P, Dijkstra G, de Jong DJ, Oldenburg B, Farhan M, Richard T, Dean Y, Hommes DW; Initiative on Crohn's and Colitis, The Netherlands. Phase I, double-blind, randomized, placebo-controlled, dose-escalation study of NI-0401 (a fully human anti-CD3 monoclonal antibody) in patients with moderate to severe active Crohn's disease. Inflamm Bowel Dis. 2010 Oct;16(10):1708-16.
Beauvillain C et al. The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells. J Hepatol (2010), doi:10.1016/j.jhep.2009.11.031
2009
Crabé S, Guay-Giroux A, Tormo AJ, Duluc D, Lissilaa R, Guilhot F, Mavoungou-Bigouagou U, Lefouili F, Cognet I, Ferlin W, Elson G, Jeannin P, Gauchat JF. The IL-27 p28 Subunit Binds Cytokine-Like Factor 1 to Form a Cytokine Regulating NK and T Cell Activities Requiring IL-6R for Signaling. J Immunol. 2009 7692-7702
Jana Pachlopnik Schmid, Chen-H. Ho, Fabrice Chrétien, Juliette M. J Lefebvre, Gérard Pivert, Marie Kosco-Vilbois, Walter Ferlin, Frédéric Geissmann, Alain Fischer, Geneviève de Saint Basile Neutralization of IFNγ defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice Published online on May 04, 2009 DOI: 10.1002/emmm.200900009 (p 112-124)
Ungaro R, Fukata M, Hsu D, Hernandez Y, Breglio K, Chen A, Xu R, Sotolongo J, Espana C, Zaias J, Elson G, Mayer LF, Kosco-Vilbois M, Abreu MT. A novel toll-like receptor 4 (TLR4) antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol. 2009 Apr 9. [Epub ahead of print]
Séverine Fagète, Ulla Ravn, Franck Gueneau, Giovanni Magistrelli, Marie H. Kosco-Vilbois and Nicolas Fischer 2009.Specificity tuning of antibody fragments to neutralize two human chemokines with a single agent mAbs Volume 1, Issue 3: May/June 2009
Sandanger, O., L. Ryan, J. Bohnhorst, A. C. Iversen, H. Husebye, O. Halaas, L. Landro, P. Aukrust, S. S. Froland, G. Elson, A. Visintin, O. Oktedalen, J. K. Damas, A. Sundan, D. Golenbock, and T. Espevik. 2009. IL-10 enhances MD-2 and CD14 expression in monocytes and the proteins are increased and correlated in HIV-infected patients. J. Immunol. 182: 588-595
2008
Figge, M. T., A. Garin, M. Gunzer, M. Kosco-Vilbois, K. M. Toellner, and M. Meyer-Hermann. 2008. Deriving a germinal center lymphocyte migration model from two-photon data. J. Exp. Med. 205: 3019-3029
Fischer N. New magic bullets can hit more han one target. 2008. Expert Opin. Drug Discov. 3(8):833-839
Franich, J., N. J. Krautler, E. Heinen, M. Polymenidou, C. Bridel, A. Schildknecht, C. Huber, M. H. Kosco-Vilbois, R. Zinkernagel, G. Miele, and A. Aguzzi. 2008. Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8. J. Exp. Med. 205: 1293-1302
Nitschke, C., A. Garin, M. Kosco-Vilbois, and M. Gunzer. 2008. 3D and 4D imaging of immune cells in vitro and in vivo. Histochem. Cell Biol. 130: 1053-1062
Smith, L. S., O. Kajikawa, G. Elson, M. Wick, S. Mongovin, M. Kosco-Vilbois, T. R. Martin, and C. W. Frevert. 2008. Effect of Toll-like receptor 4 blockade on pulmonary inflammation caused by mechanical ventilation and bacterial endotoxin. Exp. Lung Res. 34: 225-243
Spiller, S., G. Elson, R. Ferstl, S. Dreher, T. Mueller, M. Freudenberg, B. Daubeuf, H. Wagner, and C. J. Kirschning. 2008. TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice. J. Exp. Med. 205: 1747-1754
Tissieres, P., I. Dunn-Siegrist, M. Schappi, G. Elson, R. Comte, V. Nobre, and J. Pugin. 2008. Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria. Blood 111: 2122-2131
Wolfs, T. G., I. Dunn-Siegrist, C. van't Veer, C. M. Hodin, W. T. Germeraad, M. A. van Zoelen, R. J. van Suylen, C. J. Peutz-Kootstra, G. Elson, J. Pugin, and W. A. Buurman. 2008. Increased release of sMD-2 during human endotoxemia and sepsis: a role for endothelial cells. Mol. Immunol. 45: 3268-327
2007
Daubeuf, B., J. Mathison, S. Spiller, S. Hugues, S. Herren, W. Ferlin, M. Kosco-Vilbois, H. Wagner, C. J. Kirschning, R. Ulevitch, and G. Elson. 2007. TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock. J. Immunol. 179: 6107-6114
Dunn-Siegrist, I., O. Leger, B. Daubeuf, Y. Poitevin, F. Depis, S. Herren, M. Kosco-Vilbois, Y. Dean, J. Pugin, and G. Elson. 2007. Pivotal involvement of Fcgamma receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1. J. Biol. Chem. 282: 34817-34827
Elson, G., I. Dunn-Siegrist, B. Daubeuf, and J. Pugin. 2007. Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria. Blood 109: 1574-1583
Fischer N. and Leger O. Bispecific Antibodies: Molecules That Enable Novel Therapeutic Strategies 2007. Pathobiology 74:3-14
Macedo, L., G. Pinhal-Enfield, V. Alshits, G. Elson, B. N. Cronstein, and S. J. Leibovich. 2007. Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors. Am. J. Pathol. 171: 1774-1788
Schwickert, T. A., R. L. Lindquist, G. Shakhar, G. Livshits, D. Skokos, M. H. Kosco-Vilbois, M. L. Dustin, and M. C. Nussenzweig. 2007. In vivo imaging of germinal centres reveals a dynamic open structure. Nature 446: 83-87
2006
Gaspal, F. M., F. M. McConnell, M. Y. Kim, D. Gray, M. H. Kosco-Vilbois, C. R. Raykundalia, M. Botto, and P. J. Lane. 2006. The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand. Eur. J. Immunol. 36: 1665-1673
Pene, J., F. Guilhot, I. Cognet, P. Guglielmi, A. Guay-Giroux, J. Y. Bonnefoy, G. C. Elson, H. Yssel, and J. F. Gauchat. 2006. Detection of epsilon class switching and IgE synthesis in human B cells. Methods Mol. Biol. 315: 319-329
Rose-John, S., J. Scheller, G. Elson, and S. A. Jones. 2006. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J. Leukoc. Biol. 80: 227-236
Steffens, S., F. Burger, G. Pelli, Y. Dean, G. Elson, M. Kosco-Vilbois, L. Chatenoud, and F. Mach. 2006. Short-term treatment with anti-CD3 antibody reduces the development and progression of atherosclerosis in mice. Circulation 114: 1977-1984
2005
Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors. Jeannin P, Bottazzi B, Sironi M, Doni A, Rusnati M, Presta M, Maina V, Magistrelli G, Haeuw JF, Hoeffel G, Thieblemont N, Corvaia N, Garlanda C, Delneste Y, Mantovani A. Immunity. 2005 May;22(5):551-60.
Cognet, I., F. Guilhot, M. Gabriac, S. Chevalier, Y. Chouikh, A. Herman-Bert, A. Guay-Giroux, S. Corneau, G. Magistrelli, G. C. Elson, H. Gascan, and J. F. Gauchat. 2005. Cardiotrophin-like cytokine labelling using Bir A biotin ligase: a sensitive tool to study receptor expression by immune and non-immune cells. J. Immunol. Methods 301: 53-65
de, B. B., D. Derouet, J. F. Gauchat, G. Elson, H. Gascan, and O. Delapeyriere. 2005. clc is co-expressed with clf or cntfr in developing mouse muscles. Cell Commun. Signal. 3: 1
Kajikawa, O., C. W. Frevert, S. M. Lin, R. B. Goodman, S. M. Mongovin, V. Wong, K. Ballman, B. Daubeuf, G. Elson, and T. R. Martin. 2005. Gene expression of Toll-like receptor-2, Toll-like receptor-4, and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia. Gene 344: 193-202
Krawczyk, M., K. Masternak, M. Zufferey, E. Barras, and W. Reith. 2005. New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study. Mol. Cell Biol. 25: 8607-8618
Magistrelli, G., F. Gueneau, M. Muslmani, U. Ravn, M. Kosco-Vilbois, and N. Fischer. 2005. Chemokines derived from soluble fusion proteins expressed in Escherichia coli are biologically active. Biochem. Biophys. Res. Commun. 334: 370-375
2004
Detection of circulating soluble CD28 in patients with systemic lupus erythematosus, primary Sjögren's syndrome and systemic sclerosis. Hebbar M, Jeannin P, Magistrelli G, Hatron PY, Hachulla E, Devulder B, Bonnefoy JY, Delneste Y. Clin Exp Immunol. 2004 May;136(2):388-92.
Cognet, I., F. Guilhot, S. Chevalier, A. Guay-Giroux, A. Bert, G. C. Elson, H. Gascan, and J. F. Gauchat. 2004. Expression of biologically active mouse ciliary neutrophic factor (CNTF) and soluble CNTFRalpha in Escherichia coli and characterization of their functional specificities. Eur. Cytokine Netw. 15: 255-262
Ferlin, W. G., E. Mougneau, S. Hugues, H. Appel, M. H. Jang, J. Cazareth, L. Beaudoin, C. Schricke, A. Lehuen, K. W. Wucherpfennig, and N. Glaichenhaus. 2004. Self-peptides that bind with low affinity to the diabetes-associated I-A(g7) molecule readily induce T cell tolerance in non-obese diabetic mice. Eur. J. Immunol. 34: 2656-2663
Kosco-Vilbois, M. H. 2004. A mightier mouse with human adaptive immunity. Nat. Biotechnol. 22: 684-685
Krawczyk, M., N. Peyraud, N. Rybtsova, K. Masternak, P. Bucher, E. Barras, and W. Reith. 2004. Long distance control of MHC class II expression by multiple distal enhancers regulated by regulatory factor X complex and CIITA. J. Immunol. 173: 6200-6210
Martinez-Soria, E., N. Ibnou-Zekri, M. Iwamoto, M. L. Santiago-Raber, S. Kikuchi, M. Kosco-Vilbois, and S. Izui. 2004. Epitope-dependent inhibition of T cell activation by the Ea transgene: an explanation for transgene-mediated protection from murine lupus. J. Immunol. 173: 2842-2848
Muhlethaler-Mottet, A., M. Krawczyk, K. Masternak, C. Spilianakis, A. Kretsovali, J. Papamatheakis, and W. Reith. 2004. The S box of major histocompatibility complex class II promoters is a key determinant for recruitment of the transcriptional co-activator CIITA. J. Biol. Chem. 279: 40529-40535
Perret, D., C. Guillet, G. Elson, J. Froger, H. Plun-Favreau, F. Rousseau, M. Chabbert, J. F. Gauchat, and H. Gascan. 2004. Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines. J. Biol. Chem. 279: 43961-43970
Pugin, J., S. Stern-Voeffray, B. Daubeuf, M. A. Matthay, G. Elson, and I. Dunn-Siegrist. 2004. Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood 104: 4071-4079
Rousseau, P., K. Masternak, M. Krawczyk, W. Reith, J. Dausset, E. D. Carosella, and P. Moreau. 2004. In vivo, RFX5 binds differently to the human leucocyte antigen-E, -F, and -G gene promoters and participates in HLA class I protein expression in a cell type-dependent manner. Immunology 111: 53-65
